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We report mixing characterization of five lab-scale and eight production-scale static mixers using a modified fourth Bourne reaction. An efficient inline method relying on UV–vis spectroscopy was developed to streamline analysis of the product distribution. As a result of these studies, we have designed, 3D-printed, and characterized a stainless steel static mixer. This approach enabled the evaluation of different configurations and ensured efficient scale-up across development and commercial facilities that should allow for enhanced portability of mixing-sensitive processes.

Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry

François Lévesque* , Nicholas J. Rogus*, Glenn Spencer, Plamen Grigorov, Jonathan P. McMullen, David A. Thaisrivongs , Ian W. Davies^†, and John R. Naber

Process Research and Development, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.8b00063

*E-mail: francois.levesque@merck.com., *E-mail: nicholas_rogus@merck.com.

https://pubs.acs.org/doi/10.1021/acs.oprd.8b00063

https://pubs.acs.org/doi/suppl/10.1021/acs.oprd.8b00063/suppl_file/op8b00063_si_001.pdf

Associate Principal Scientist at Merck

François Lévesque

//////////////FLOW CHEMISTRY,

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