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DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER
Jan 162020
 

Graphical abstract: An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis

 

An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis

Green Chem., 2020, Advance Article

DOI: 10.1039/C9GC03564H, Paper
Zhikang Wu, Yongyan Zhai, Wenshu Zhao, Zheyu Wei, Han Yu, Sheng Han, Yongge Wei
A green and highly efficient N-formylation of amines using formic acid as the acylating agent by iron catalysis with excellent selectivity and yields.
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An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis

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Abstract

The first example of an inorganic-ligand supported iron(III) catalysed coupling of formic acid and amines to form formamides is reported. The pure inorganic catalyst (NH4)3[FeMo6O18(OH)6] (1), which consists of a central FeIII single-atomic core supported within a cycle-shaped inorganic ligand consisting of six MoVIO6 octahedra, shows excellent activity and selectivity, and avoids the use of complicated/commercially unavailable organic ligands. Various primary amines and secondary amines have been successfully transformed into the corresponding formamides under mild conditions, and the formylation of primary diamines has also been achieved for the first time. The Fe catalyst 1 can be reused several times without appreciable loss of activity.

STR1

Image result for Zhikang Wu School of Chemical and Environmental Engineering Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, P.R. China

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