Ethyl 4, 6-dichloro-1H-indole-2-carboxylate

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Ethyl 4, 6-dichloro-1H-indole-2-carboxylate

ethyl 4,6-dichloro-1H-indole-2-carboxylate (1a) (2.70 kg, 99.5%).

Mp 187–188 °C; HRMS (ESI) m/z [M – H]⁻ calcd for C₁₁H₈NO₂Cl₂ 255.9927, found 255.9930;

¹H NMR (400 MHz, DMSO-d₆) δ 12.41 (s, 1H), 7.44 (s, 1H), 7.27 (s, 1H), 7.10 (s, 1H), 4.43–4.30 (q, 2H), 1.34 (d, 3H);

¹³C NMR (151 MHz, CDCl₃) δ 161.69, 137.08, 131.00, 128.45, 128.37, 125.31, 121.26, 110.52, 107.07, 61.56, 14.32;

IR (cm^–1) 3314.3, 2987.6, 1700.2, 1615.8, 1566.2, 1523.7, 1487.2, 1323.3, 1247.2, 1072.4, 840.1, 770.2.

https://pubs.acs.org/doi/suppl/10.1021/acs.oprd.8b00144/suppl_file/op8b00144_si_001.pdf

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