Jun 042013
An efficient, telescopic, and scalable process for an antihypertensive drug substance, valsartan with an overall yield of 58%, and 
99.9% purity is described. A simple, and safe process is developed for the recovery of tributyltin chloride from the tributyltin hydroxide, byproduct formed in the tetrazole ring construction, and reused in the synthesis of valsartan.
Dr. Reddy’s Laboratories
Org. Process Res. Dev., 2012, 16 (4), pp 682–686
DOI: 10.1021/op3000306
Publication Date (Web): March 5, 2012
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