Type-2 diabetes is a severe metabolic disease caused by the loss of the cells producing the hormone insulin. Since this molecule controls the up-take of glucose from the circulation, diabetic patients accumulate pathological levels of sugar in their blood.
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Researchers use modified RNA transfection to correct genetic dysfunction in heart stem cells derived from Barth syndrome patients. The series of images show how inserting modified RNA into diseased cells causes the cells to produce functioning versions of the TAZ protein (first image: in green) that correctly localize in the mitochondria (second image: in red). When the images are merged to demonstrate this localization, green overlaps with red, giving the third image a yellow color. (Credit: Gang Wang and William Pu/Boston Children’s Hospital)
Harvard scientists have merged stem cell and ‘organ-on-a-chip’ technologies to grow, for the first time, functioning human heart tissue carrying an inherited cardiovascular disease. The research appears to be a big step forward for personalized medicine, as it is working proof that a chunk of tissue containing a patient’s specific genetic disorder can be replicated in the laboratory.
The work, published in Nature Medicine, is the result of a collaborative effort bringing together scientists from the Harvard Stem Cell Institute, the Wyss Institute for Biologically Inspired Engineering, Boston Children’s Hospital, the Harvard School of Engineering and Applied Sciences, and Harvard Medical School. It combines the ‘organs-on-chips’ expertise of Kevin Kit Parker, PhD, and stem cell and clinical insights by William Pu, MD.
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1-((3-methoxyphenyl)sulfonyl)piperidine (2) is a crystalline white solid
1-((3-Methoxyphenyl)sulfonyl)piperidine: Piperidine,
1-[(3-methoxyphenyl)sulfonyl]-; (2) cas no (173681-65-7)
mp 115-116 °C;
1H NMR pdf
(400 MHz, DMSO-d6, 2.50 ppm)
δ: 1.30-1.35 (m, 2 H, N(CH2CH2)2CH2),
1.47-1.52 (m, 4 H, N(CH2CH2)2CH2),
2.85 (t, J = 5.2 Hz, 4 H, N(CH2CH2)2CH2),
3.83 (s, 3 H, OMe),
7.16 (t, J = 2.1 Hz, 1 H, Ar-H),
7.25-7.30 (m, 2 H, Ar-H),
7.55 (t, J = 8.0 Hz, 1 H, Ar-H);
13C NMR pdf
(100 MHz, DMSO-d6, 39.5 ppm)
δ: 22.8, 24.7, 46.6, 55.6, 112.3, 118.7, 119.5, 130.5, 136.7, 159.5;
IR nmax (film)/cm-1 2940, 2851, 1597, 1478, 1359, 1340, 1318, 1287, 1241, 1167, 1098, 1040, 931, 856, 724, 688; (principal peaks);
HRMS (FTMS+p-NSF) found m/z 256.1002 [M+H]+, C12H18 NO3S requires m/z 256.1002.
Reverse phase HPLC analysis reveals purity >99% (run on an Agilent Zorbax SB-C18, 5 µm, 4.6 x 150 mm column (23 °C) at a flow rate of 1.5 mL/min of 75:25 MeCN:H2O observed at 210 nm giving a retention time of 1.95 min, 1.0 mg/mL in MeCN).
Reference s
Microgel-based thermoresponsive membranes for water filtration
This file photo provided by the National Institute for Allergy and Infectious Diseases shows a colorized transmission of the MERS coronavirus that emerged in 2012. Health officials on Friday, May 2, 2014 said the deadly virus from the Middle East has turned up for the first time in the U.S. (AP Photo/National Institute for Allergy and Infectious Diseases via The Canadian Press, File)
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Multifunctional microcapsules made from metals and tannic acid