AUTHOR OF THIS BLOG

DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Worlddrugtracker, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT ,1991, Mumbai, India, in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA as ADVISOR earlier GLENMARK LS Research centre as consultant,Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now sSanofi, Searle India ltd, now Rpg lifesciences, etc. he is now helping millions, has million hits on google on all organic chemistry websites. His New Drug Approvals, Green Chemistry International, Eurekamoments in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has several international drug patents published worldwide . He gas good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, polymorphism etc He suffered a paralytic stroke in dec 2007 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on +91 9323115463, [email protected]

Polyketide Synthase Secrets Revealed Structural Enzymology: Findings could aid engineering of multienzyme complexes for drug discovery

 drugs  Comments Off on Polyketide Synthase Secrets Revealed Structural Enzymology: Findings could aid engineering of multienzyme complexes for drug discovery
Jun 242014
 
09225-notw1-schematic_17033141-159

ENZYME FACTORY
During PKS biosynthesis, ACP moves to AT to pick up an extender group and then delivers it to KS. In KS’s active site, the group is added to pentaketide. ACP then takes the fused product to KR, where it is reduced. Finally, ACP offers the extended product to PKS’s next module. Active sites on enzyme domains are yellow.
Credit: Adapted from Nature

Polyketide Synthase Secrets Revealed

Structural Enzymology: Findings could aid engineering of multienzyme complexes for drug discovery
A new study solves long-standing mysteries about how bacterial natural-product-making factories are put together and how they work. The findings could accelerate efforts to engineer these workshops to produce novel bioactive agents for drug discovery.
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AZD 6564 in preclinical for Antifibrinolytics

 Uncategorized  Comments Off on AZD 6564 in preclinical for Antifibrinolytics
Jun 232014
 

Abstract Image

AZD 6564

ACS Med. Chem. Lett., 2014, 5 (5), pp 538–543
DOI: 10.1021/ml400526d

SYNTHESIS SUPP INFO…..http://pubs.acs.org/doi/suppl/10.1021/ml400526d/suppl_file/ml400526d_si_001.pdf

NMR PG 16/32 AS ABOVE

Figure imgf000012_0002R1 = NEOPENTYL R2=H

5-[(2R,4S)-2-(2,2-Dimethylpropyl)piperidin-4-yl]-1,2-oxazol-3(2H)-one

5-((2R,4S)-2-Neopentylpiperidin-4-yl)isoxazol-3(2H)-one

238.326

C13 H22 N2 O2

Antifibrinolytics

AstraZeneca (Innovator)

SYNTHESIS SUPP INFO…..http://pubs.acs.org/doi/suppl/10.1021/ml400526d/suppl_file/ml400526d_si_001.pdf

NMR PG 16 0F 32

……………………..

Discovery of the fibrinolysis inhibitor AZD6564, acting via interference of a protein – Protein interaction
ACS Med Chem Lett 2014, 5(5): 538

http://pubs.acs.org/doi/abs/10.1021/ml400526d

Abstract Image

A class of novel oral fibrinolysis inhibitors has been discovered, which are lysine mimetics containing an isoxazolone as a carboxylic acid isostere. As evidenced by X-ray crystallography the inhibitors bind to the lysine binding site in plasmin thus preventing plasmin from binding to fibrin, hence blocking the protein–protein interaction. Optimization of the series, focusing on potency in human buffer and plasma clotlysis assays, permeability, and GABAa selectivity, led to the discovery of AZD6564 (19) displaying an in vitro human plasma clot lysis IC50 of 0.44 μM, no detectable activity against GABAa, and with DMPK properties leading to a predicted dose of 340 mg twice a day oral dosing in humans.

SUPP INFO…..http://pubs.acs.org/doi/suppl/10.1021/ml400526d/suppl_file/ml400526d_si_001.pdf

 

Step 9: 5,((2R,4S),2,Neopentylpiperidin,4,yl)isoxazol,3(2H),one

Starting from (2R,4S),methyl 2,neopentyl,4,(3,oxo,2,3,dihydroisoxazol,5,
yl)piperidine,1,
carboxylate (0.8 g, 2.7 mmol) and following the procedure described in 15, Step8
the title
compound was obtained (0.44 g, 69 %):
1H NMR (600 MHz, DMSO,d6) δ 0.92 (s, 9H), 1.11 –1.34 (m, 3H), 1.35 – 1.46 (m, 1H), 1.79 – 1.98 (m, 2H), 2.65 – 2.93 (m, 3H),
3.03 – 3.14 (m,1H), 5.74 (s, 1H);13C NMR (101 MHz, CH4,d4) δ 177.39, 174.72, 95.42, 54.83, 49.32, 45.50,
37.13, 34.75, 31.19, 30.07, 28.06;
[α]20D+43.8 (MeOH/H2O 1:1, c = 1); HRMS calculated for[C13H23N2O2]+: 239.1759; found: 239.1753
Compounds of formula I- V may be prepared by the following route:Scheme A. Preparation of intermediatesMETHOD A

Figure imgf000015_0001

O

L C^O”

 

Figure imgf000015_0002

METHOD B

O

Figure imgf000015_0003

 

Figure imgf000015_0004

METHOD C

 

Figure imgf000016_0001

METHOD D

RIB(OR)2

 

Figure imgf000016_0002

X = Cl, Br

 

Figure imgf000016_0003

METHOD E

Figure imgf000017_0001

METHOD F

Figure imgf000017_0002

METHOD G

 

Figure imgf000018_0001

R1 = 1-methyl-1 H-tetrazol-5-yl and 2-methyl-2H-tetrazol-5-yl

Scheme B. Formation of 5-isoxazol-3-ones

°Y I ‘relative

Figure imgf000019_0001
Figure imgf000019_0002

°Y J ‘relative

Figure imgf000019_0003

………………….

http://www.google.com/patents/EP2417131A1?cl=en

Example 14

5-((2R,4S)-2-Neopentylpiperidin-4-yl)isoxazol-3(2H)-one

Step 1 : Cis-methyl 2-neopentyl-4-(3-oxo-23-dihvdroisoxazol-5-yl)piperidine-l-carboxylate The compound was prepared as described in Example 1, Step 2 starting from cis-methyl 4-(3- ethoxy-3-oxopropanoyl)-2-neopentylpiperidine-l -carboxylate (2.68 g, 8.19 mmol) which resulted in cis-methyl 2-neopentyl-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-l- carboxylate (1.60 g, 66 %) : IH NMR (400 MHz, cdcl3) δ 0.89 (s, 9H), 1.18 (dd, IH), 1.45 (dd, IH), 1.80 – 1.92 (m, 2H), 1.97 – 2.17 (m, 2H), 2.94 – 3.02 (m, IH), 3.11 – 3.23 (m, IH), 3.71 (s, 3H), 3.88 – 3.99 (m, IH), 4.22 – 4.32 (m, IH), 5.72 (s, IH); m/z (MH+) 297.

Step 2: (2R,4S)-Methyl 2-neopentyl-4-(3-oxo-2,3-dihvdroisoxazol-5-yl)piperidine-l- carboxylate

Following the procedure described in Example 1, Step 3, racemic cis-methyl 2-neopentyl-4- (3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-l -carboxylate (1.60 g, 5.4 mmol) was subjected to chiral separation using Chiralcel IC mobile phase heptane/IP A/FA 60/40/0.1 which resulted in (2R,4S)-methyl 2-neopentyl-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-l-carboxylate (0.8 g, 2.7 mmol).

Step 3: 5-((2R,4S)-2-Neopentylpiperidin-4-yl)isoxazol-3(2H)-one

5 Starting from (2R,4S)-methyl 2-neopentyl-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-l- carboxylate (0.8 g, 2.7 mmol) and following the procedure described in Example 1, Step 4 the title compound was obtained (0.44 g, 69 %): 1H NMR (600 MHz, DMSO-d6) δ 0.89 (s, 9H), 1.18 (m, 2H), 1.50 (m, 2H), 1.82-1.90 (m, 2H), 2.70-2.85 (m, 3H), 3.08 (m, IH), 5.71 (s, IH). [α]20 D +43.8 (MeOH/H2O 1:1, c = 1); HRMS calculated for [C13H23N2O2]+: 239.1759; found: 10 239.1753.

 

ANTHONY MELVIN CRASTO

THANKS AND REGARD’S
DR ANTHONY MELVIN CRASTO Ph.D

[email protected]

MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA
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Black Fungus Health Benefits (Anticancer Remedy)

 cancer  Comments Off on Black Fungus Health Benefits (Anticancer Remedy)
Jun 212014
 

Black fungus is a very common type of edible mushroom which is found in Nigeria and other parts of the world. It grows on trees mostly in the rural areas due to the vast untapped vegetation found there. –

See more at: http://www.dobbyssignature.com/2012/06/black-fungus-health-benefits-anticancer.html#sthash.MrRk0WH7.dpuf

http://www.dobbyssignature.com/2012/06/black-fungus-health-benefits-anticancer.html

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A Glass of Wine Against Dental Caries?

 Uncategorized  Comments Off on A Glass of Wine Against Dental Caries?
Jun 202014
 

thumbnail image: A Glass of Wine Against Dental Caries?

A Glass of Wine Against Dental Caries?

Moderate concentrations of red wine inhibit the growth of pathogens causing dental caries

Read more

http://www.chemistryviews.org/details/news/6286181/A_Glass_of_Wine_Against_Dental_Caries.html

 

 

 

 

 

 

 

 

BRAZIL WORLDCUP WEEK 2014

 

 

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Worldwide Hepatitis C Market: CV Drugs Clinical Trials, Hepatitis C Pipeline Drugs Sales & Forecast 2018

 Uncategorized  Comments Off on Worldwide Hepatitis C Market: CV Drugs Clinical Trials, Hepatitis C Pipeline Drugs Sales & Forecast 2018
Jun 192014
 
WhaTech Channel: Reports Industrial
Published: Wednesday, 18 June 2014 20:34
Submitted by Market Research WhaTech Premium
News from: RnR Market Research

Hepatitis C market by 2018 is expected to grow more than 3 times from its current market size of 2012. Hepatitis C virus (HCV) infection is a complex public health problem, characterized by a high prevalence of chronic infection, an increasing burden of HCV-associated disease, low rates of testing, treatment and the prospect of increasing incidence associated with the epidemic of injection drug use.

http://www.whatech.com/members-news/reports-industrial/22195-worldwide-hepatitis-c-market-cv-drugs-clinical-trials-hepatitis-c-pipeline-drugs-sales-forecast-2018

Hepatitis C Market Overview

Hepatitis C is a leading cause of chronic liver disease, end-stage cirrhosis and liver cancer. Because of the slow progression and asymptomatic character of the infection, many people are unaware of having it. As a consequence, the infection is often diagnosed at a late stage when treatment options are limited. As no effective vaccine against the Hepatitis C virus (HCV) has been discovered so far the market is driven by therapeutics. The increase in the prevalence of the disease and the availability of new first-in-class therapies with better safety and efficacy profiles are expected to drive the growth of the HCV market. The growth in HCV drugs market is primarily attributed to high unmet need in the market which is expected to be fulfilled by strong pipeline candidates. Low levels of awareness and knowledge about HCV have been identified as a formidable challenge to prevention and care.

Complete report is available @ http://www.rnrmarketresearch.com/hepatitis-c-market-forecast-hcv-drugs-clinical-trials-hepatitis-c-pipeline-drugs-sales-forecast-worldwide-market-report.html .

Renub Research study titled “Hepatitis C Market & Forecast, HCV Drugs Clinical Trials, Hepatitis C Pipeline Drugs Sales & Forecast – Worldwide” provides a comprehensive assessment of the fast-evolving, high-growth of Hepatitis sector. This 164 page report with 25 Figures and 2 Tables studies the Hepatitis C Drug Market Landscape. This report contains 7 chapters.

  • Hepatitis C Drugs Market & Forecast (Chapter 2)
  • Hepatitis C Approved Drugs Sales & Forecast (Chapter 3)
  • Hepatitis C Deals & Acquisitions (Chapter 4)
  • Hepatitis C – Pipeline Drugs Clinical Trials (Drugs in Phase III) (Chapter 5)
  • Hepatitis C – Pipeline Drugs Clinical Trials (Drugs in Phase II) (Chapter 6)
  • Hepatitis C – Pipeline Drugs Sales Forecast (Chapter 7)

Hepatitis C – Approved Drugs sales & Forecast Analysis (To 2016) (Chapter No. 3)

  1. Pegasys
  2. Pegintron
  3. Incivek
  4. Victrelis

Hepatitis C – Pipeline Drugs Clinical Trials (Drugs in Phase III) (Chapter No. 5)

  • Simeprevir (TMC 435) (Company: Janssen Pharmaceutical)
  • Faldaprevir (BI 201335) (Company: Boerhinger Ingelheim)
  • Asunaprevir (BMS-650032) (Company: Bristol-Myers Squibb)
  • PEG-Interferon Lambda (Company: Bristol-Myers Squibb)
  • Sofosbuvir (PSI-7977 or GS-7977) (Company: Gilead Sciences)
  • Daclatasvir (BMS-790052) (Company: Bristol-Myers Squibb)
  • BI-207127 (Company: Boerhinger Ingelheim)
  • ABT-450/r (Ritonavir) (Company: Abbott Laboratories)
  • ABT-267 (Company: Abbott Laboratories)
  • ABT-072/333 (Company: Abbott Laboratories)
  • Alisporivir (Company: Novartis)

Purchase a copy of this report @ http://www.rnrmarketresearch.com/contacts/purchase?rname=186104 .

Hepatitis C – Pipeline Drugs Clinical Trials (Drugs in Phase II) (Chapter No. 6)

  • Mericitabine (RG-7128) (Company: Roche)
  • Danoprevir/r (Ritonavir) (RG7227) (Company: Roche)
  • GS-9256 (Company: Gilead Sciences)
  • GS-9451 (Company: Gilead Sciences)
  • MK-5172 (Company: Merck)
  • Sovaprevir (ACH-1625) (Company: Achillion)
  • IDX-320 (Company: Idenix)
  • MK-8742 (Company: Merck)
  • ACH-3102 (Company: Achillion Pharmaceuticals, Inc)
  • IDX-719 (Company: Idenix)
  • PPI-668 (Company: Presidio Pharmaceuticals)
  • Setrobuvir (ANA-598) (Company: Roche)
  • VX-222 (Company: Vertex Pharmaceuticals)
  • GS-9669 (Company: Gilead Sciences)
  • GS-9190 (Tegobuvir) (Company: Gilead Sciences)
  • BMS-791325 (Company: Bristol-Myers Squibb)

Hepatitis C – Pipeline Drugs Sales Forecast (Chapter 7)

  • Simeprevir (TMC 435)
  • Faldaprevir (BI 201335) (Boerhinger Ingelheim)
  • Asunaprevir (BMS-650032)
  • Sofosbuvir (PSI-7977 or GS-7977)
  • Daclatasvir (BMS-790052)
  • ABT-450/r (Ritonavir)
  • ABT-072/333
  • Alisporivir
  • Mericitabine (RG-7128)
  • Danoprevir (RG7227)
  • GS-9256
  • Setrobuvir (ANA-598)
  • VX-222
  • GS-9190 (Tegobuvir)
  • BMS-791325

Data Sources

This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by Renub Research team of industry experts.

Primary sources include industry surveys and telephone interviews with industry experts.

Secondary sources information and data has been collected from various printable and non-printable sources like search engines, News websites, Government Websites, Trade Journals, White papers, Government Agencies, Magazines, Newspapers, Trade associations, Books, Industry Portals, Industry Associations and access to more than 500 paid databases.

News From

RnR Market Research
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AmVac begins Phase III trial of Gynevac vaccine for bacterial vaginosis

 Phase 3 drug, Uncategorized, VACCINE  Comments Off on AmVac begins Phase III trial of Gynevac vaccine for bacterial vaginosis
Jun 192014
 
AmVac begins Phase III trial of Gynevac vaccine for bacterial vaginosis
AmVac has commenced a Phase III study of its Gynevac to assess the safety and efficacy of the vaccine in bacterial vaginosis (BV) treatment.

AmVac has commenced a Phase III study of its Gynevac to assess the safety and efficacy of the vaccine in bacterial vaginosis (BV) treatment.

Image

Manufactured in accordance with the current GMP standards, the therapeutic vaccine is based on a blend of inactivated lactobacilli strains.

http://www.marketwatch.com/story/amvac-initiates-phase-iii-trial-with-its-lead-vaccine-gynevac-for-the-treatment-of-bacterial-vaginosis-2014-06-17

 

Love, cast in stone: Temples in India depicting erotic art

India is dotted with many glorious temples, but erotica on the walls of some arouses curiosity and even puzzles tourists. There are various theories about the reason for such vivid depiction of erotica–mass sex education, warding off natural calamities and the devdasi system. Due to the presence of 64 Yogini temples near Khajuraho, Padawali, Konarak/Lingaraj etc., scholars also attribute the erotic art to Tantric practices, which revolve around the ultimate union of the male and the female energy and forms referred to as Maithuna. Whatever the reason be, the brazenness or ethereal beauty of temple erotica will never cease to amaze us.

Khajuraho, Madhya Pradesh

Built by the Chandela Kings who were greatly influenced by Tantric traditions, this temple is said to represent the ultimate seductress.

While the fine sandstone statues built earlier have a well rounded finish, the ones made later are more angular. In his history of the Kamasutra, Mc Connachie describes the amorous sculptures as “the apogee of erotic art”, where the twisting, broad hipped and high breasted nymphs, fleshy apsaras and extravagantly interlocked maithunas run riot along the surface of stone.

The various scenes of passionate love making, in acrobatic postures that sometimes border on the physically impossible, strike viewers. Look out for the bold panels of multiple partners engaged with each other. For an interesting perspective on Khajuraho, watch the Sound and Light show. The best time to visit is during the Khajuraho Dance Festival in the first week of February.

Markandeshwar Temple, Maharashtra

Near the naxal district of Gadchiroli, the Markandeshwar temple complex, by the River Wainganga, showcases a sprinkling of erotic art. A couple performing ‘fellacio’ will raise eyebrows. Know to be built by danavas (evil forces) in one night, the temple is made from stone, and follows Hemadpanth architecture. The annual fair during Mahashivratri attracts devotees from far and wide every year. Hiring a car from Nagpur is recommended, unless you fancy hitch-hiking with villagers past moonlit fields or changing several buses and autos. If you’re stranded, look for the dharamshala near the temple.

Padawali Temple,  Madhya Pradesh

In Morena district near the Chambal Valley, once notorious for dacoits, lies the fortress of Padawali. Two stalwart lion statues greet you at its entrance. The temple inside has earned the reputation being a ‘Mini Khajuraho’ due to the prevalence of erotic art. The difference between big brother Khajuraho and Padawali Temple, is that the erotic art here seems less acrobatic and more ‘real life’ and ‘doable’. The carvings of maithunas in various positions, ranging from simple to difficult almost brings the Kamasutra to life.

Ranakpur Jain Temples, Rajasthan

This marble temple of superlative beauty is a ‘vision in white’ with its domes, shikharas and turrets. Over 1,444 intricately carved marble pillars hold up the temple and a monolithic marble rock depicting over 100 snakes catches the eye. Look out for a panel depicting several experimental love making scenes, in a line with a central queen-like figure seated on a throne, with an amorous midget on her lap. It’s interesting to note that not only Hindus, but even Jains decorated temples with erotic art. It hints at how nudity had a religious connect due to the ‘Digambara’ ideology or the Tantric cult.

Sun Temple,  Orissa 

When I first visited the Sun Temple at Konarak in Orissa, as a giggly 16-year-old , I was  taken aback by how the panels revealed way more about the ‘birds and bees’ than our biology classes had taught us. My second visit recently, helped me appreciate the beautiful erotic art better. The brazenness of the sculptures here gives Khajuraho stiff competition; one of the most scandalous panels is of a dog licking a woman’s genital area. I overheard a guide say, “this was considered a cure for sex related infections, as the dog’s saliva has antibiotic properties.” Scenes of polygamy, polyandry and lesbian love are blissfully abundant.

An architectural genius, this temple shows the Sun God on a colossal chariot drawn by seven horses. The word Konarak is a combination of Kona (corner) and Arka (Sun).  The temple was previously located closer to the sea, but the magnetic properties of its stone caused shipwrecks. This, along with the dark colour of its stones, earned it the tile of ‘The Black Pagoda’. An interesting study in contrast is the famous Jagannath Temple at Puri, also referred to as ‘The White Pagoda’ due to its whitewashed walls. If you are an art enthusiast you must visit the Konarak Archaeological Museum nearby that contains fallen sculptures from the temple.

Sun Temple, Gujarat

It is believed to be the place where Lord Rama conducted a yagna here to purify himself of the sin of killing a Brahmana-Ravana. Like Konarak, its architecture is such that the temple catches the first rays of the rising sun. The most striking feature of the temple is a perfectly designed Kama Kunda (water tank) meant for ablutions and for a reflection of the temple in the water. It has lateral stone steps leading down to the tank, allowing both direct and diagonal descent from all sides. Carvings of men and women in various acts of sex with small midget like creatures are prominent. However, due to erosion the detailing of the stone carvings is blurred in places.

Osian, Rajasthan

Amidst the sand dunes of Thar, Osian has a cluster of Hindu and Jain temples dating back to the 11 century AD. The Sachiya Mata temple dedicated to the resident Goddess has a gorgeous carved archway leading up to the shrine and has some beautiful depiction of erotic love locked couples, complete with details like the bed on which the couples lie.

Virupaksha Temple, Karnataka
On the banks of the Tungabhadra River, this temple with beautiful pillars and towered gateways dedicated to Lord Shiva in his avatar as Virupaksha. It is one of the oldest functioning temples since the 7th century AD. A  panel  that catches the eyes depicts a nude woman being ‘admired’ by men and women around her. It is best to visit the temple, during the Hampi festival in November. While in the area, also check out the erotic art on the pillars of the Achyutaraya temple.

Several other temples in South India like Belur, Halebidu, Somanathapura and Nugguhalli, the Badami and Banashankari temples of the Chalukya times and the Vijayanagar temples of Bhatkal and Lepakshi also have a profusion of erotic art. The Meenakshi temple of Madurai and Veeraranarayan temple of Gadag have erotic sculptures on their Gopuram. (Information about other temples with erotic art in South India taken from www.kamat.com)

No one has summed up the beauty of erotica on temple walls better than Tagore while he was referring to Konarak, ‘The language of man here is defeated by the language of stone.’

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Mesocrystals as a class of multifunctional materials

 Uncategorized  Comments Off on Mesocrystals as a class of multifunctional materials
Jun 192014
 

Graphical abstract: Mesocrystals as a class of multifunctional materials

 

Mesocrystals that consist of crystallographically aligned individual building blocks and controlled level of porosity in between exhibit unique structures and multifunctional behavior. A large number of mesocrystals have been successfully developed by different growth technologies, and various growth mechanisms are discussed. In addition to various self-assembly and growth techniques, considerable attention has been paid to the formation mechanisms where the crystalline colloidal nanoparticles are assembled into mesocrystals via interparticle forces or physical fields. Owing to their high surface area, controllable level of porosity, crystallinity of subunits, oriented subunit alignment, and elegant 3D network structure, the performance of mesocrystals may be superior to their nanocrystalline, single-crystal, and polycrystalline counterparts. There has been a surge in the number of applications demonstrated for mesocrystals over the past couple of years, showing their great application potential.

 

Mesocrystals as a class of multifunctional materials

Yanqiong Liu,a   Yu Zhanga and   John Wang*a
*Corresponding authors
aDepartment of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, Singapore 117574
E-mail: [email protected];
Fax: +65 6776 3604 ;
Tel: +65 6516 1268
CrystEngComm, 2014,16, 5948-5967

DOI: 10.1039/C4CE00256C

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