January 24, 2015 – All About Drugs

All About Drugs

Tout sur les médicaments הכל על תרופות كل شيئ عن الأدوية Все о наркотиках 关于药品的一切 డ్రగ్స్ గురించి అన్ని 마약에 관한 모든 것 Όλα για τα Ναρκωτικά Complete Tracking of Drugs Across the World by Dr Anthony Melvin Crasto, Worldpeacepeaker, worlddrugtracker, PH.D (ICT), MUMBAI, INDIA, Worlddrugtracker, Helping millions, 9 million hits on google on all websites, 2.5 lakh connections on all networks, “ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

7 Semi-synthesis of artemisinin using continuous flow. The Seeberger group has recently developed a continuous flow approach to the production of …

In the developing world, multi-drug resistant malaria caused by the parasite Plasmodium falciparum is an epidemic that claims the lives of 1–3 million people per year. Artemisinin, a naturally occurring small molecule that has seen little resistance from malarial parasites, is a valuable weapon in the fight against this disease. Several easily accessible artemisinin derivatives, including artesunate and artemether, display potent antimalarial activity against drug-resistant malaria strains; however, the global supply of artemisinin from natural sources alone remains highly inconsistent and unreliable. As a result, several approaches to artemisinin production have been developed, spanning areas such as total synthesis, flow chemistry, synthetic biology, and semi-synthesis. This review highlights achievements in all areas, in addition to the interplay between synthetic biology and synthetic chemistry that has fueled the recent industrial-scale production of artemisinin.

Synthetic chemistry fuels interdisciplinary approaches to the production of artemisinin

Michael A. Corsello*^a and Neil K. Garg*^a

http://pubs.rsc.org/en/content/articlelanding/2015/np/c4np00113c#!divAbstract

Corresponding authors

^aDepartment of Chemistry and Biochemistry, University of California, Los Angeles, USA

E-mail: mcorsello@ucla.edu, neilgarg@chem.ucla.edu

Nat. Prod. Rep., 2015, Advance Article

DOI: 10.1039/C4NP00113C

Neil garg

http://www.chem.ucla.edu/dept/Faculty/garg/Garg_Group/About_Neil.html

Michael A. Corsello

Improving chemical synthesis using flow reactors.

Expert Opin Drug Discov

Expert Opin Drug Discov 2007 Nov;2(11):1487-503

Charlotte Wiles, Paul Watts

Charlotte

Prof Paul Watts

http://www.pubfacts.com/fulltext_frame.php?PMID=23484600&title=Improving%20chemical%20synthesis%20using%20flow%20reactors.

Owing to the competitive nature of the pharmaceutical industry, researchers involved in lead compound generation are under continued pressure to identify and develop promising programmes of research in order to secure intellectual property.

The potential of a compound for therapeutic development depends not only on structural complexity, but also on the identification of synthetic strategies that will enable the compound to be prepared on the desired scale.

One approach that is of present interest to the pharmaceutical industry is the use of continuous flow reactors, with the flexible nature of the technology being particularly attractive as it bridges the changes in scale required between the initial identification of a target compound and its subsequent production.

Based on these factors, a significant programme of research is presently underway into the development of flow reactors as tools for the synthetic chemist, with the transfer of many classes of reaction successfully reported to date.

This article focuses on the application of continuous flow methodology to drug discovery and the subsequent production of pharmaceuticals.