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DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

Development of a Safe and Robust Process for the Large-Scale Preparation of a Vinyl Bromide from a Ketone Using a (PhO)3P/Br2-Derived Reagent

 SYNTHESIS  Comments Off on Development of a Safe and Robust Process for the Large-Scale Preparation of a Vinyl Bromide from a Ketone Using a (PhO)3P/Br2-Derived Reagent
May 072016
 
Abstract Image

The large-scale synthesis of ethyl 4-bromocyclohex-3-enecarboxyalate, using a mild brominating reagent derived from triphenyl phosphite and bromine, is reported. The development and comparison of both continuous and batch processes are described.

A modified addition sequence was developed based on the knowledge garnered from flow-processing, resulting in a safe and efficient process for the in situ generation of the unstable active reagent and its immediate reaction with the ketone in a batch mode process.

Development of a Safe and Robust Process for the Large-Scale Preparation of a Vinyl Bromide from a Ketone Using a (PhO)3P/Br2-Derived Reagent

Chemical and Synthetic Development, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore-560099, India
Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.6b00100

http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00100

 

Authors

Nachiket Likhite

Nachiket Likhite

Senior Research Investigator at Bristol-Myers Squibb Biocon R&D Center (BBRC)

KIRAN SHAW…OWNER

/////Development, Safe and Robust Process, Large-Scale Preparation,  Vinyl Bromide,  Ketone,  (PhO)3P/Br2-Derived Reagent

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