An Integrated Synthesis–Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery
http://www.akademiai.com/content/r1t41145nn051252/?p=27bf59e482ec4093985c1e9ec3df3aba&pi=1
| Flow Chemistry | |
| Issue | Volume 1, Number 2/December 2011 |
| Pages | 56-61 |
| DOI | 10.1556/jfchem.2011.00013 |
Authors
1Structural Chemistry, Advanced Technology, Global Research and Development, Abbott Laboratories 100 Abbott Park Road 60064 Abbott Park, IL USA
2Medicinal Chemistry Technologies, Advanced Technology, Global Research and Development, Abbott Laboratories 100 Abbott Park Road 60064 Abbott Park, IL USA
3Automation Engineering, Advanced Technology, Global Research and Development, Abbott Laboratories 100 Abbott Park Road 60064 Abbott Park, IL USA
Abstract
We report herein a high-throughput integrated ynthesis–purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmented-flow synthesizer was integrated to a preparative HPLC-MS, where each reaction product was purified immediately upon reaction completion. Further, automated structure-validation processes accelerate the rate at which drug discovery candidates are available for biological screening.
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