Synthesis of Phospholipopeptides
A crosslinking approach for the synthesis of phospholipopeptides under mild conditions
http://www.chemistryviews.org/details/news/7984971/Synthesis_of_Phospholipopeptides.html
Bonan Li and Jun F. Liang, Stevens Institute of Technology, Hoboken, NJ, USA, report an approach to synthesize phospholipopeptides. They use a crosslinker with a thiol-reactive maleimide and an amine-reactive N-hydroxysuccinimide ester (pictured). Hence, the molecule is able to link the thiol group of the amino acid cystein in the peptide and the amine group of the phospholipid (phosphatidylamine).
