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DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

Safe and Fast Flow Synthesis of Functionalized Oxazoles with Molecular Oxygen in a Microstructured Reactor

 flow synthesis, SYNTHESIS  Comments Off on Safe and Fast Flow Synthesis of Functionalized Oxazoles with Molecular Oxygen in a Microstructured Reactor
Jun 242016
 
Abstract Image

The synthesis of hydroperoxymethyl oxazoles by oxidation of alkylideneoxazoles with molecular oxygen was implemented in a microstructured reactor for increased safety and larger-scale applications. Elaborate studies on the influence of pressure and temperature were performed, and the apparent activation energy for the oxidation reaction was determined. Elevated temperatures up to 100 °C and pressures up to 18 bar(a) led to a conversion rate of approximately 90% within 4 h of the reaction time, thus displaying the high potential and beneficial effect of using a microreactor setup with liquid recycle loop for this oxidation. The in situ reduction of the generated hydroperoxide functionality shows the capability of this setup for follow-up transformations.

Oxazole–hydroperoxide 3as a colorless solid. Rf (PE/EA 3:1 = 0.31).

1H NMR (30 MHz, CDCl3) δ = 4.98 (s, 2H), 7.12 (s, 1H), 7.49–7.29 (m, 3H), 7.88–7.75 (m, 2H), 10.16 (s, 1H). GC-MS (EI) m/z = 173.1 (M – OH), 144.1 (M – CH2OOH), 116.1 (M – C6H5 + 2H), 89.1.

 

STR1

Safe and Fast Flow Synthesis of Functionalized Oxazoles with Molecular Oxygen in a Microstructured Reactor

Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg,Germany
Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
§ Chemistry Department, Faculty of Science, King Abdulaziz University (KAU), 21589 Jeddah, Saudi Arabia
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.6b00118
*E-mail: t.roeder@hs-mannheim.de. Telephone: +49 621 292 6800.
Siegel
Organisch-Chemisches Institut                                    
Im Neuenheimer Feld 270
69120 Heidelberg
Germany
Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany

Panorama picture of the Campus in July 2006

 

Thorsten Röder

Prof. Dr.
Professor (Full)

Research experience

  • Sep 2009–present
    Professor (Full)
    Hochschule Mannheim · Institute of Chemical Process Engineering
    Germany · Mannheim
  • Sep 2005–Aug 2009
    Laboratory Head
    Novartis · Chemical and Analytical Process Development
    Switzerland · Basel
  • Sep 1999–Aug 2004
    PhD Student
    Universität Paderborn · Department of Chemistry · Physical Chemistry Prof. Kitzerow
    Germany · Paderborn
 Teaching experience
  • Sep 2009–present
    Professor (Full)
    Hochschule Mannheim · Institute of Chemical Process Engineering
    Germany
    Lectures in: Chemical Reaction Engineering Thermodynamic Microreactors & Nanotechnology CFD Practical Course: Chemical Reaction Engineering

Education

  • Oct 1999–Oct 2004
    Universität Paderborn
    Physical Chemistry · Dr. rer. nat.
    Germany · Paderborn
  • Sep 1994–Sep 1999
    Universität Paderborn
    Chemistry · Diplom Chemiker
    Germany
Hashmi Stephen 160x200

Prof. Dr. A. Stephen K. Hashmi

E-Mail hashmi@hashmi.de

/////////Safe and Fast,  Flow Synthesis, Functionalized Oxazoles, Molecular Oxygen, Microstructured Reactor

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