AUTHOR OF THIS BLOG

DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER
Jan 012015
 

IMAGE……….http://www.laboratorytalk.com/life-sciences-and-clinical-laboratory-equipment/synthesis-systems/flow-chemistry-system-aids-synthesis-of-cns-drugs/404882.article

 

 

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Gleevec, developed by Novartis, is a tyrosine kinase inhibitor used for the treatment of chronic myeloid leukaemia and gastrointestinal stromal tumours. The drug molecule represents a particularly challenging target for flow chemistry because of the low solubility of many of the reaction components required for its synthesis. The team devised a new synthesis route that prevents the equipment blockages from product precipitation and avoids many of the labour and time intensive practices of traditional batch-based preparation.

 

flow synthesisThe flow-based route required minimal manual intervention and was achieved despite poor solubility of many reaction componentsLINK………...http://www.rsc.org/chemistryworld/2013/01/flow-synthesis-anticancer-drug

2…………………..

Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

  1. Dr. François Lévesque1 and
  2. Prof. Dr. Peter H. Seeberger1,2,*

Article first published online: 16 JAN 2012

DOI: 10.1002/anie.201107446………….http://onlinelibrary.wiley.com/doi/10.1002/anie.201107446/abstract

 

 

IMAGE………..http://phys.org/news/2013-08-chemists-fresh-approach-alloy-nanomaterials.html

 

 

 

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http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-9-265

 

 

IMAGE……..http://www.chemistryviews.org/details/ezine/1058453/Women_in_ChemistryA_European_Journal.html

 

 

4…………………….

 

http://www.rsc.org/chemistryworld/2014/09/antimalarial-flow-synthesis-commercialisation-artemisinin

 

 

 

 

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http://pipeline.corante.com/archives/2014/04/

 

http://www.chemistryviews.org/details/ezine/5753931/Liliana_Mammino_Research_and_Education_in_Sub-Saharan_Africa.html

 

 

 

6…………………………

http://pubs.rsc.org/en/content/articlelanding/2013/ob/c2ob27003j#!divAbstract

 http://www.amnh.org/learn-teach/young-naturalist-awards/winning-essays2/2013-winning-essays/optimizing-algae-biofuels-applied-natural-selection-to-improve-lipid-synthesis

 

 

 

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http://onlinelibrary.wiley.com/doi/10.1002/anie.201305429/abstract

http://www.rsc.org/chemistryworld/2012/04/iron-lady

 

 

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http://www-medchem.ch.cam.ac.uk/hot_topics.php

http://www.ollusa.edu/s/1190/ollu.aspx?pgid=2674

 

 

 

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http://www.mdpi.com/1420-3049/19/7/9736

http://www.ed.ac.uk/alumni/services/news/news/femalechemists

 

 

 

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http://newdrugapprovals.org/2014/12/31/continuous-flow-synthesis-of-alpha-halo-ketones-building-blocks-for-anti-retroviral-agents/

main image

 

http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_26-9-2013-11-6-53

 

 

 

 

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http://pubs.rsc.org/en/content/articlehtml/2013/ob/c3ob41464g

 

http://emmittnlxe.soup.io/

 

 

 

 

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http://pubs.rsc.org/en/content/articlelanding/2012/sc/c2sc21850j#!divAbstract

 

IMAGE……..http://evnewsreport.com/tag/battery/

 

 

 

 

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http://www.leygroup.ch.cam.ac.uk/research/continuous-flow-methodology/heterocycles-flow

IMAGE……….http://www.chemistryviews.org/details/ezine/1059875/Women_in_Chemistry__Interview_with_Zeinab_Shaaban_Abd_El-Ati_Abou_El-Naga.html

 

 

 

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http://www.sfu.ca/chemistry/groups/britton/publications.html

 

 

 

IMAGE……….http://www.greentechnolog.com/green_chemistry/

 

 

 

 

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