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DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

Structural and physicochemical aspects of hydrochlorothiazide co-crystals

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Jul 172014
 

Structural and physicochemical aspects of hydrochlorothiazide co-crystals

CrystEngComm, 2014, 16,6996-7003
DOI: 10.1039/C4CE00666F, Paper
*

Corresponding authors

aPharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

The drug-drug co-crystal of hydrochlorothiazide with pyrazinamide is a potential candidate for development of hydrochlorothiazide formulations for combinational therapy.

Crystal engineering principles were employed in designing new co-crystals of hydrochlorothiazide (HCT). A variety of potential co-crystal formers were initially identified in a search of the Cambridge Structural Database with complementary hydrogen-bonding functionalities. Subsequent co-crystallization screening monitored by powder X-ray diffraction led to the discovery of new crystalline phases of HCT with pyrazinamide (1), 4,4′-bipyridine (2), 1,2-bis(4-pyridyl)ethane (3), and trans-1,2-bis(4-pyridyl)ethylene (4). All of the resulting co-crystals were thoroughly characterized by X-ray diffraction, FT-IR and Raman spectroscopy, and thermal analysis. Noticeably, the co-crystal 1 involves the formation of drug–drug co-crystals of HCT and pyrazinamide, which makes it a potential candidate for development of HCT formulations for combinational therapy.
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The crystal structure and optical properties of a pharmaceutical co-crystal – the case of the melamine–barbital addition compound

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Jun 162014
 

 

Graphical abstract: The crystal structure and optical properties of a pharmaceutical co-crystal – the case of the melamine–barbital addition compound

 

The crystal structure and optical properties of a pharmaceutical co-crystal – the case of the melamine–barbital addition compound

M. Gryl, T. Seidler, K. Stadnicka, I. Matulková, I. Němec, N. Tesařová and P. Němec

CrystEngComm, 2014, 16, 5765 DOI:10.1039/C4CE00178H

The melamine barbital co-crystal is a product of crystal engineering of non-linear optical materials composed of pharmaceutically active ingredients. The resulting crystal phase shows a non-linear effect higher than that of KDP. The material was characterized by means of X-ray diffraction and optical property measurements and calculations.

Graphical abstract: The crystal structure and optical properties of a pharmaceutical co-crystal – the case of the melamine–barbital addition compound

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CE/C4CE00178H?utm_medium=email&utm_campaign=pub-CE-vol-16-issue-26&utm_source=toc-alert#!divAbstract

The crystal structure and optical properties of a pharmaceutical co-crystal – the case of the melamine–barbital addition compound

*Corresponding authors
aDepartment of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland 
bDepartment of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 40 Prague 2, Czech Republic
cDepartment of Chemical Physics and Optics, Faculty of Mathematics and Physics, Charles University in Prague, Ke Karlovu 3, 121 16 Prague 2, Czech Republic
CrystEngComm, 2014,16, 5765-5768

DOI: 10.1039/C4CE00178H

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