Sep 202018
4-(2-fluoro-4-nitrophenyl)morpholine
1H NMR (400MHz, CDCl3) 8.03 (ddd J=1.0, 2.6 and 9.0Hz, 1H, ArH), 7.94 (dd J=2.6 and 13.1Hz, 1H, ArH), 6.94 (t J=8.7Hz, 1H, ArH), 3.90 (t J=4.7Hz, 4H, 2xCH2O), 3.31 (m, 4H, 2xCH2N).
13C NMR (100MHz, CDCl3) 153.3 (d J=249.5), 145.6 (d J=7.8Hz), 121.1 (d J=3.0Hz), 117.0 (d J=3.9Hz), 112.7 (d J=6.4Hz), 66.7, 50.0 (d J=4.9Hz).
HRMS [M] Calcd for C10H11FN2O3 226.0748, Found 226.0749.
Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)
James Gardiner, Xuan Nguyen, Charlotte Genet, Mike D. Horne, Christian H. Hornung, and John Tsanaktsidis
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.8b00153
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