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Enantioselective organocatalytic reactions published in the recent patent literature are highlighted in this review and include inter- and intramolecular phase-transfer conjugate additions catalyzed by quaternized cinchona alkaloids, a Diels–Alder reaction catalyzed by oxazaborolidine complexes, asymmetric Betti reactions, the Lonza synthesis of l-carnitine, and several Corey–Bakshi–Shibata reductions.

Asymmetric Organocatalysis in Drug Development—Highlights of Recent Patent Literature

David L. Hughes* 

Cidara Therapeutics, Inc., 6310 Nancy Ridge Drive, Suite 101, San Diego, California 92121, United States

Org. Process Res. Dev., 2018, 22 (5), pp 574–584

DOI: 10.1021/acs.oprd.8b00096

Publication Date (Web): April 19, 2018

Copyright © 2018 American Chemical Society

*E-mail: dhughes@cidara.com.

https://pubs.acs.org/doi/10.1021/acs.oprd.8b00096

///////////////Asymmetric Organocatalysis

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