AUTHOR OF THIS BLOG

DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER
Nov 112017
 

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Axay Parmar

Axay Parmar

Founder at Synthesis with Catalysts Pvt. Ltd

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Synthesis with Catalysts Pt. Ltd. is a company started with an aim to produce chiral and achiral precious metal based catalysts on commercial scale in line with “Clean and Green India” and “Make in India” vision of Government of India. These catalysts have been developed to promote efficient, economical and environmentally benign processes for the target compounds being produced in aroma, fine chemicals and pharmaceutical industries. These catalysts and their intermediates are also extensively used in academic and industrial R&D centres across globe. In India these catalysts are currently imported at a very prohibitive cost, due to which their use is limited for want of funds. In this direction Synthesis with Catalysts Pvt. Ltd. is striving to make these products available to indigenously available at a very competitive price at small and bulk scale. We are also doing in-house research to optimize process parameters ofvarious organic transformations particularly asymmetric hydrogenation and isomerization reactionsfor customers as and when required.

For the list of our products please visit our wesitewww.synthesiswithcatalysts.com

ABOUT US

  • Our vision is to be the most respected catalyst manufacturing company in the country
  • Our goal is to help our customers:
  • to further improve their production methodologies
  • increase productivity,
  • develop new products with the intervention of catalysts to make the process green and clean
  • Highly selective catalysts for intended application
  • Competitive pricing with short delivery lead times
  • Custom product and process development

Activities:A

Manufacture of Homogeneous catalysts using metal ions viz. Rh, Pt, Ir, Pd, Ru, Co, and Mn

Manufacture of ligands and intermediates

Pharmaceutical, bulk drugs, API, aroma chemical, essential oil industries served

Focus on chiral chemistries

Gram to kilogram quantities

ASYMMETR

Some of the representative reactions are:

ASYMMETRIC/ CHEMOSELECTIVE HYDROGENATION CATALYSTS

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Statements

  • Catalysts are chiral metal complexes derived from a precious metal ion and chiral ligands
  • Ru used most frequently, Rh used in some cases to enhance chemo- and enantio- selectivity
  • Chiral ligands can be selected from variety of simple and substituted BINAP alone or in combination with chiral/achiral diamines
  • Suggested catalysts:
    • RuCl2[(S)-BINAP](dmf)n
    • RuCl2[(S)- tolBINAP][(S,S)-dpen]
    • (S)-XylBINAP/(S)-DAIPEN-Ru
    • (S)-XylBINAP/(S,S)-DPEN-Ru
    • RuCl2[(S)-tolBINAP](pica)
    • RuCl[(S,S)-TsDPEN](η6-p-cymene)
    • Ru(OTf)(TsDPEN)(p-cymene)
    • BINAP-Ru(II) dicarboxylate complexes

ENANTIOSELECTIVE EPOXIDATION / HKR / DKR

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Statements:

  • Transition metal complexes are used for chiral and non-chiral epoxidation of internal and prochiral olefins
  • The epoxides are important intermediates for host of industrially important products
  • In cases where epoxides are required in high optical purity, racemic epoxides can be subjected to Hydrolytic kinetic resolution (HKR), Aminolytic kinetic resolution (AKR), Dynamic kinetic resolutions (DKR)
  • Suggested catalysts:
    • Mn, Co, Cr, Al complexes of chiral SALEN ligands

ASYMMETRIC ISOMERIZATION

 

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Double bond migration reactions

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Statements:

  • Rh-catalyzed asymmetric isomerization of allylic amines into the corresponding enamines is one of the most revered industrial organic transformation in asymmetric catalysis
  • It has accommodated a wide range of substrates and is a key step in the industrial production of menthol
  • Other industrially important isomerization is migration of terminal double bond to produce selectively trans-internal olefins
  • Commercially important products like isoeugenol and trans-anetheole are produced by these transformations
  • Suggested catalysts:
    • Ru(acac)3
    • RuHCl(CO)(PPh3)3
    • Rh/Pd complexes

Tree of popular asymmetric organic transformations

 

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At Chiral India event in Mumbai where our technical director Dr. Abdi Is a speaker. With Basu Agarwal

Basu Agarwal

Basu Agarwal

CEO at Synthesis with Catalysts Pvt Ltd
Phone 9999972051 (Mobile)
Email
IM basu.ag@gmail.com (Google Talk)
Chiral India 2017, Nov7-8 Ramada plaza palm grove, Juhu, Mumbai, India

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“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

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