Sep 052015
The synthesis of complex molecules requires control over both chemical reactivity and reaction conditions. While reactivity drives the majority of chemical discovery, advances in reaction condition control have accelerated method development/discovery. Recent tools include automated synthesizers and flow reactors. In this Synopsis, we describe how flow reactors have enabled chemical advances in our groups in the areas of single-stage reactions, materials synthesis, and multistep reactions. In each section, we detail the lessons learned and propose future directions.
Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis
† Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
‡ Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany
§ Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States
J. Org. Chem., 2013, 78 (13), pp 6384–6389
DOI: 10.1021/jo400583m
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