Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

 

 

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

J. Hartwig, J.B. Metternich, N. Nikbin, A. Kirschning, S.V. Ley, Org. Bio. Chem. 2014, 12, 3611

http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/c4ob00662c#!divAbstract

Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity pattern and extended reaction scope has been achieved by transferring a reaction from batch mode to flow. This new reactivity can be explained by suppressing back mixing and precise control of temperature in a flow reactor set up.