AUTHOR OF THIS BLOG

DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER
Oct 282014
 

 

 

 

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substitutedguanidines from in situ generated iminophosphoranes.

Graphical abstract: Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

 

Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process 

C.D. Smith, I.R. Baxendale, G.K. Tranmer, M. Baumann, S.C. Smith, R.A. Lewthwaite and S.V. Ley, Org. Biomol. Chem., 2007, 5, 1562-1568.

http://pubs.rsc.org/en/content/articlelanding/2007/ob/b703033a/unauth#!divAbstract

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  One Response to “Tagged Phosphine Reagents to Assist Reaction Work-up by Phase-Switched Scavenging Using a Modular Flow Reactor Process”

  1. Interesting. More needed innovation.

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